ChemicalBook > CAS DataBase List > (1S,2R)-(-)-cis-1-Amino-2-indanol
(1S,2R)-(-)-cis-1-Amino-2-indanol
Reaction- Product Name
- (1S,2R)-(-)-cis-1-Amino-2-indanol
- CAS No.
- 126456-43-7
- Chemical Name
- (1S,2R)-(-)-cis-1-Amino-2-indanol
- Synonyms
- (1S,2R)-1-AMINO-2,3-DIHYDRO-1H-INDEN-2-OL;(1S,2R)-1-AMINO-2-INDANOL;(1S,2R)-CIS-1-AMINO-2-INDANOL;(1S,2R)-(-)-1-AMINO-2-INDANOL;CIS-(1S,2R)-1-AMINO-2-INDANOL;(1S;3aR;(1S,2R) -(−KT-1-Amino-2-indanol-0001;5R)-LGH447 dihydrochloride
- CBNumber
- CB6417161
- Molecular Formula
- C9H11NO
- Formula Weight
- 149.19
- MOL File
- 126456-43-7.mol
More
Less
(1S,2R)-(-)-cis-1-Amino-2-indanol Property
- Melting point:
- 118-121 °C(lit.)
- alpha
- -62 º (c=0.5, CHCl3)
- Boiling point:
- 270.27°C (rough estimate)
- Density
- 1.0753 (rough estimate)
- refractive index
- 1.5760 (estimate)
- RTECS
- NK7525500
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- 14.79±0.40(Predicted)
- form
- Powder
- color
- White to light beige
- optical activity
- [α]20/D 61°, c = 0.5 in chloroform
- Water Solubility
- slightly soluble
- Sensitive
- Air Sensitive
- BRN
- 4292559
- InChIKey
- LOPKSXMQWBYUOI-BDAKNGLRSA-N
- CAS DataBase Reference
- 126456-43-7(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-36/37/39
- RIDADR
- 3259
- WGK Germany
- 3
- F
- 10-23
- TSCA
- No
- HazardClass
- 8
- HS Code
- 29052900
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 440833
- Product name
- (1S,2R)-(?)-cis-1-Amino-2-indanol
- Purity
- 99%
- Packaging
- 1g
- Price
- $26
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 440833
- Product name
- (1S,2R)-(?)-cis-1-Amino-2-indanol
- Purity
- 99%
- Packaging
- 5g
- Price
- $27.1
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A1624
- Product name
- (1S,2R)-(-)-1-Amino-2-indanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $30
- Updated
- 2024/03/01
TCI Chemical
- Product number
- A1624
- Product name
- (1S,2R)-(-)-1-Amino-2-indanol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $131
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- H32066
- Product name
- (1S,2R)-(-)-cis-1-Amino-2-indanol, 97%
- Packaging
- 5g
- Price
- $146.65
- Updated
- 2024/03/01
More
Less
(1S,2R)-(-)-cis-1-Amino-2-indanol Chemical Properties,Usage,Production
Reaction
- Ligand component used in the chromium-catalyzed highly selective asymmetric ene reactions between aryl aldehydes and alkoxy- and silyloxyalkenes.
- Ligand component for the chromium-catalyzed highly enantioselective o inverse-demand hetero-Diels-Alder reactions of α,β-unsaturated aldehydes.
- Ligand component for the magnesium-catalyzed conjugate addition reaction of 1,3-dicarbonyl compounds to nitroalkenes.
- Component for stereoselective asymmetric 6π-azaelectrocyclization through the reaction between the (E)-3-
- carbonyl-2,4,6-trienal compounds and the (-)-7-alkyl-cis-1-amino-2-indanol derivatives.
- Ligand component for palladium-catalzyed asymmetric azaelectrocyclization for the preparation of 2,4-
- disubstituted chiral 1,2,5,6-tetrahydropyridines.
- Component for organocatalytic conjugate addition of formaldehyde N,N-dialkylhydrazones to β,γ -Unsaturated α-keto esters.
- N-Sulfinyl urea organocatalyst component for enantioselective aza-henry reaction.
- Component for organocatalytic enantioselective additions of indoles to nitroalkenes.
Chemical Properties
white to light yellow crystal powder
Uses
1S,2R)-(-)-cis-1-Amino-2-indanol may be used to prepare:
- (-)-1,2,5,6-Tetrahydropyridine by reacting with methyl (E,E)-4-oxo-2-[(2,6,6-trimethylcyclohex-1-enyl)vinyl}but-2-enoate.
- Oxazaborolidine catalysts, which can catalyze the asymmetric reduction of aromatic ketones with high enantioselectivity.
- (RS,1S,2R)-(-)-2,4,6-Trimethylbenzenesulfinic acid 1-(2,4,6-trimethylbenzenesulfonylamino)indan-2-yl ester.
Uses
(1S,2R)-(-)-cis-1-Amino-2-indanol is used as a reagent in the synthesis of heterocyclic compounds as integrase inhibiting antiviral agents. It is also a key intermediate of the HIV protease inhibitor, Indinavir (I525000).
General Description
(1S,2R)-(-)-cis-1-Amino-2-indanol is a main constituent of indinavir, a potent HIV (human immunodeficiency virus) protease inhibitor.
(1S,2R)-(-)-cis-1-Amino-2-indanol Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
(1S,2R)-(-)-cis-1-Amino-2-indanol Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10194
- Advantage
- 62
- Tel
- +1-510-219-6317
- Fax
- +1-650-486-1361
- sales@hbcchem.com
- Country
- United States
- ProdList
- 10658
- Advantage
- 60
- Tel
- +1(858) 699-3322
- Fax
- +1(858) 876-1948
- marketing@accelachem.com
- Country
- United States
- ProdList
- 6027
- Advantage
- 65
- Tel
- (+1)-858-699-3322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 19965
- Advantage
- 58
- Tel
- 8485655694
- sales@alchempharmtech.com
- Country
- United States
- ProdList
- 63711
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
- Tel
- +1-817863-6948 +1-（817）863-6948
- sales@aceschem.com
- Country
- United States
- ProdList
- 19639
- Advantage
- 58
More
Less
View Lastest Price from (1S,2R)-(-)-cis-1-Amino-2-indanol manufacturers
Ouhuang Engineering Materials (Hubei) Co., Ltd
- Product
- (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol 126456-43-7
- Price
- US $5.00/kg
- Min. Order
- 1kg
- Purity
- 99.92%
- Supply Ability
- 50000tons
- Release date
- 2024-04-29
Ouhuang Engineering Materials (Hubei) Co., Ltd
- Product
- (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.10%
- Supply Ability
- 50000kg
- Release date
- 2024-04-23
Hebei Mojin Biotechnology Co., Ltd
- Product
- (1S,2R)-(-)-cis-1-Amino-2-indanol 126456-43-7
- Price
- US $100.00/kg
- Min. Order
- 25kg
- Purity
- 99.99%
- Supply Ability
- 200ton
- Release date
- 2023-07-28
126456-43-7, (1S,2R)-(-)-cis-1-Amino-2-indanolRelated Search:
Aminopyrine
Sulfamic acid
2-Indanol
Glycine
4-Amino-benzenesulfonic acid monosodium salt
EC 2.6.1.2
6-Aminocaproic acid
Acetaminophen
ALTRENOGEST
2-Aminophenol
Tris(hydroxymethyl)aminomethane
Glucosamine
Indinavir
tert-Butanesulfinamide
TERT-BUTYLSULFONAMIDE
N-[N,O-ISOPROPYLIDENE-(2R)-HYDROXY INDAN-(1S)-YL]-(2R)-BENZYL-(4S,5)-EPOXY PENTANAMIDE
[1(1S,2R),5(S)]-2,3,5-Trideoxy-N-(2,3-dihydro-2-hydroxy-1H-inden-1-yl)-5-[2-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide
3-(CHLOROMETHYL)PYRIDINE